Root Causes Of Brain Inflammation
According to Harvard researcher Datis Kharrazian, PhD, DHSc, author of Why Isnt My Brain Working?, a compromised blood-brain barrier is one of the greatest risk factors for brain inflammation.
The blood-brain barrier is a finely woven mesh of specialized cells and blood vessels that seek to keep foreign substances out of the brain.
But this barrier can become damaged, making it permeable or leaky.
This allows toxins and pathogens to enter the brain, which in turn activates the microglia to produce inflammation.
This barrier permeability also allows inflammation that originates elsewhere in the body to enter the brain and start the inflammation response there.
According to Dr. Kharrazian, here are some of the risk factors that can activate microglia to produce brain inflammation:
Management Of Allergies And Allergic Inflammation
The two key elements of allergy management are preventing the exposure of sensitized individuals to allergen and treating these individuals with therapeutic agents appropriate to the disorder. For example, antihistamines that target the H1 histamine receptor are a mainstay of treatment for allergic rhinitis but have been of limited value in asthma,. Asthma is generally treated with inhaled corticosteroids and agonists of -adrenergic receptors . These treatments are effective in many subjects,. Some patients with asthma are helped by drugs that target cys-LTs,. Omalizumab, which targets IgE, helps some subjects with moderate or severe asthma and is being evaluated in other settings.
The extent to which pharmacogenetic approaches can be used to understand the basis of variable clinical responses to the same agent, and to identify subjects who will benefit from particular treatments, is an area of active investigation. Allergen-specific immunotherapy should be considered in situations in which this approach has been shown to be beneficial,.
You Experience Brain Fog
If we are talking about chronic inflammation due to lifestyle and/or toxins, brain fog and slowed cognitive skills may be some signs to look out for. When you have brain fog, you might lose your train of thought easily and you’ll have trouble focusing on your everyday tasks. As Carolyn Dean, MD, ND, author of 365 Ways to Boost Your Brain Power: Tips, Exercise, Advice, tells Bustle, limiting dairy consumption, sugary foods, smoking, and alcohol may help with these symptoms.
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How To Prevent Allergy Fatigue
The best way to prevent allergy fatigue is to find an effective treatment option for your allergies. The first step in managing allergies and preventing symptoms like fatigue is to find out which specific allergens trigger your reactions. After this diagnosis, there are ways to minimize allergies and avoid fatigue. You can minimize allergy fatigue in several ways:
Dairy Allergies And Sensitivities Oh My
If you produce the lactase enzyme but still react poorly to dairy, you likely have a milk protein allergy, experiencing an allergic response to one or both of the proteins found in dairycasein and whey. This type of dairy allergy is most commonly seen in children but can also affect adults and may cause symptoms such as swelling of the mouth, lips or throat, skin reactions such as hives or rashes, or increased nasal congestion and mucus production. People can also experience dairy allergy symptoms in the G.I. tract such as loose stools, diarrhea, vomiting, and/or abdominal cramping.
Since casein has a similar molecular structure to the wheat protein, gluten, 50% of people who have celiac disease also have a casein intolerance, according to older research. Simply put, if you negatively react to gluten, its more likely that youll also react to milk and dairy products because milk proteins can commonly cross-react with gluten in the intestine.
Additionally, if you have increased intestinal permeability, or leaky gut, it is more likely that your immune system may respond to potentially allergenic components in milk and dairy products. If you have small intestinal bacterial overgrowth or irritable bowel syndrome you might also negatively react to dairy and notice gas, bloating and other digestive symptoms. Going dairy free can often help manage these symptoms, at least until the condition resolves.
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Innate Immune Defense And Systemic Inflammation
The consequences of food-induced activation of the immune system can initially be subtle, but may become serious over time. The continuous intake of reactive substances causes local micro-inflammation in the intestinal tissue, which spreads insidiously and can manifest itself in other tissues. Therefore the ormonal-, the nervous and the metabolic system can be affected and symptoms may manifest in varioush forms. This makes it complex and symptoms might not be identified with food intolerance as the initial cause.
Table 1: Examples of diseases that are associated with food intolerance and activated innate immunity and
The list in table 1 reflects the experience of doctors from various disciplines and demonstrates the enormous variety of impacts of an underlined chronic, food induced immune activation resulting in associated inflammatory processes. Often, in addition to a present intolerance, over time other intolerances may occur resulting in multiple intolerances influencing each other adversely.
Lab Tests For Inflammation
- The;C-reactive protein test;is the most decisive test for detecting inflammation. This simple blood test can reveal high levels of C-reactive protein; CRP is produced by the liver in response to inflammation, infection and injury. It is available by fingerstick or blood draw.
- Food allergy testing;can uncover immune responses which may point to inflammation.
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How Can I Take Care Of Myself
- Do not delay seeking help. If you have had a previous severe allergic reaction, you may want to:
- Ask your doctor to prescribe several injection kits to treat anaphylaxis early and review the instructions with you. Keep tabs on the expiration date on the kits. Review the instructions until you are familiar with them. Carry one kit with you and keep one at home.
- Be prepared to give yourself an injection in case of an emergency. Think of this injection as something you can do to keep yourself alive long enough to reach medical attention.
- Wear a Medic Alert bracelet that warns of your allergy and tells what to do in case of an emergency. Inform your friends and co-workers of these measures.
- Avoid foods, chemicals, drugs, and other substances that have caused allergic reactions. For example, if shrimp causes an allergic reaction, dont eat shrimp or shrimp sauce. When eating at a strange place, be sure to ask about the ingredients used in the foods you are eating.
- Consider having immunotherapy in which your immune system is gradually exposed to the toxic substance to make it less harmful to you. Immunotherapy is very effective for insect allergies but not for food or drug allergies.
- Always tell your doctor and dentist about any drug allergies you have before they prescribe medication. Also tell your pharmacist about any drug allergies.
- Check labels before taking over-the-counter medicines or eating foods if you have drug or food allergies.
Drink Green Tea And Red Wine
All true teas are anti-inflammatory, but green tea is a standout because its highest in epigallocatechin gallate , a unique anti-inflammatory compound.;
Additionally, EGCG readily passes through the blood-brain barrier to protect brain cells from damage and stimulate the formation of new brain cells.;;
Red wine consumed in moderation is an important part of the Mediterranean diet.
Red wine is protective against chronic inflammation, heart disease, stroke, and diabetes.
Its health benefits are largely attributed to resveratrol, a polyphenol that shows promise for promoting heart health, brain health, and longevity.;
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Can Treating My Chronic Sinusitis Clear My Brain Fog
Throughout the year, and especially during allergy season, people across the country suffer with their allergies and sinuses. Also called a sinus infection, sinusitis can be triggered by an allergy or the common cold. One with sinusitis usually presents with swollen and/or inflamed nasal passages, headaches, facial pain, and other like symptoms.In some severe cases, patients can experience sinusitis over a period of eight to twelve weeks throughout the year, classifying them as having chronic sinusitis. In fact, according to the CDC, around 11% of the US population suffer with chronic sinusitis. With such a prevalence, more research is being done to find connections to this disease with other ailments. For example, some chronic sinusitis sufferers have described a mysterious brain fog as a symptom of their disease. With this being a debilitating, yet also seemingly unrelated symptom, patients across the country are asking, Can treating my chronic sinusitis clear my brain fog? Lets dive into what the medical research is saying on the subject:
What is Chronic Sinusitis?
- Nasal polyps
- Pain, tenderness and swelling around the facial area
- Reduced sense of smell and taste
- Ear and upper jaw pain
- Sore throat
Gluten Depression And Anxiety
Non-celiac gluten sensitivity has been linked to both depression and anxiety. In NCGS, gluten may lead to depressive symptoms by inducing abnormalities in serotonin production and causing changes in the gut microbiota.
While there is limited research about the effects of a gluten-free diet on anxiety and depression in patients with NCGS, a longitudinal study of celiac disease patients found that a one-year-long trial of a gluten-free diet significantly improved anxiety symptoms. In a small case study of patients diagnosed with celiac disease in adulthood who had previously been unsuccessful with antidepressant therapies, a gluten-free diet was found to quickly improve depressive symptoms.
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Could Depression Be An Allergic Reaction
Most people are still locked into the theory that depression is caused by a chemical imbalance in the brain;?;a shortage of feel-good neurotransmitters like serotonin that deliver messages from one neuron to another. That explanation works well for public consumption because its simple and it makes for great pharmaceutical commercials.
But depression is a whole lot more complicated than that.
For starters, theres faulty brain wiring. On functional MRIs, depressed brains display lower activity levels in the frontal lobes, responsible for cognitive processes, and higher levels of activity in the amygdala region of the brain . Depression can be associated with the loss of volume in parts of the brain, namely the hippocampus, which belongs to the limbic system . The more severe the depression, the greater the loss of brain volume. The endocrine system plays a significant role in mood disturbances. Some studies on depression have indicated a default in the hypothalamic-pituitary-adrenal axis, the region that manages the bodys response to stress. Chronic activation of the HPA is no good, as anyone with thyroid or pituitary issues will tell you.
And theres another theory has been lurking in the background for quite awhile, but is finally gaining the trust and attention of the public: that depression is an allergic reaction to inflammation.
But what is causing the inflammation?
I had nine bites.
I counted them.
But Im hardly alone.
Why Seasonal Allergies Cause ‘brain Fog’
The spring allergy season is upon us. Pollen counts are skyrocketing, sinuses are swelling, and for some of us other symptoms are creeping in as well. If youve experienced a brain fog characterized by dizziness, imbalance and fatigue during allergy season and wondered about the connection between the pollen youre inhaling and the mental murkiness, youre not alone. Science has been working the case, and although we dont have a clear picture just yet, were beginning to understand more about what happens in our brains when pollen is in the wind.
The basics of this story involve allergens and the immune system. If youre among the 30% or so of the population with seasonal allergies, your body responds to allergens as an assault and your immune system reacts by producing histamines, compounds that cause muscle contractions and blood vessel dilation. Later into the reaction, your body releases proteins called cytokines that signal the surrounding tissue to brace against the offenders.
All of this plus the activity of a few more chemicals results in inflammation, which we feel in our sinuses, nasal membranes, throats, eyes and lungs. Some of us are more sensitive to particular allergens , and the severity of reactions varies, from annoying to life threatening.
You can also try avoiding what sets you off , but for most allergy sufferers thats not much of an option.
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Does Dairy Cause Inflammation
If you have a dairy allergy, lactose intolerance, IBS, SIBO, gluten intolerance or intestinal permeability, there is evidence that dairy can promote an inflammatory response when consumed. Additionally, research supports that there is a positive link between milk consumption and the occurrence of acne and potentially eczema. For Parsley Health members with any of these conditions, we usually recommend following a dairy-free diet and eating only dairy substitutes to help alleviate symptoms.
However, overall research does not support the notion that dairy is inflammatory for people who do not have any of these conditions. Similarly, a 2019 review published in Advances in Nutrition found that dairy had no proinflammatory effects on healthy people as well as people who had diabetes or metabolic syndrome. Most recently, a 2020 review reported that eating dairy could even reduce biomarkers of inflammation in some cases, where subjects did not have inflammatory disorders or other conditions.
In fact, a 2017 review that evaluated 52 clinical studies, concluded that dairy generally has anti-inflammatory effects, except in people with known allergies or intolerances.
Additional research has found that total dairy intake could be associated with lower risk of cardiovascular disease and stroke .
How Does Anaphylaxis Occur
After contact with an allergen, blood vessels leak fluid into the area around them. As a result, blood pressure may drop suddenly. Because there is less blood flow, less oxygen reaches the brain and other vital organs. Since these organs cannot function properly, the body goes into shock. In addition, the body responds to the allergen by releasing chemicals such as histamines that cause swelling of the skin, a red rash, and severe itching. Complications of anaphylactic shock can include brain damage, kidney failure, and/or death.
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Diet And Brain Inflammation
Continually eating the wrong things can lead to general health problems, youll probably get sick more often, feel lethargic and youll eventually get brain fog. You know that feeling when you just cant focus, youre forgetful, and you just dont have any energy? Thats brain fog, and it can be an early sign of brain inflammation.
Inflammation occurs in your body when the cells of your immune system group together to fight an infection, usually seen in the form of redness and swelling.
Inflammation can be caused by or associated with the following:
- Bacterial or viral infection
- An allergic reaction to external factors such as perfumes and cleaning products
- An unhealthy gut
- Eating too many highly processed, high sugar and high salt foods
If the inflammation continues for long enough, it becomes the standard state for your body, and the condition becomes chronic. Chronic, or sustained inflammation has been linked with brain and Central Nervous System conditions such as Alzheimers disease, Parkinsons disease and multiple sclerosis.
Gluten And Neurodegenerative Disease
Through its effects on the gutbrain axis, ingestion of gluten may also predispose NCGS individuals to cognitive decline and an increased vulnerability to neurodegenerative diseases such as Alzheimers disease and Parkinsons disease. The systemic inflammation characteristic of non-celiac gluten sensitivity may promote the deposition of amyloid plaques and neurofibrillary tangles, phenomena characteristic of Alzheimers disease. In addition, a recent study has concluded that intestinal dysfunction represents one of the earliest manifestations of Parkinsons disease pathology; thus, the disease originates in the intestine and appears to spread to the brain via the gutbrain axis.
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Allergen Provocation Protocol Tissue Collection And Bronchoalveolar Lavage
Both AD and allergy are chronic disorders, and we have therefore validated a modified version of a previously described chronic model of airway-induced allergy in Balb/c and C57B6 mice, using a chronic OVA challenge protocol . Balb/c mice are prone to develop allergic reactions with high numbers of eosinophils and high IgE expression, and it is the most widely used strain in experimental allergy models . The C57B6 mouse strain was chosen because it is frequently used as background strain for transgenic mouse models for AD. The biochemical and immunohistochemical experiments described in the present study were performed on other groups of Balb/c and C57B6 mice subjected to the chronic airway-induced model of allergy described below. For each of the mouse strains, 20 mice were allocated for biochemical studies, and 10 mice were allocated for immunohistochemical studies.
Balb/c and C57B6 mice were sensitized to ovalbumin given as a single intraperitoneal injection on day 0 and 12 . The animals were then challenged daily from day 18 to day 23, and then three times per week during an additional 5-week period . Eosinophilic granulocytes were increased in bronchoalveolar lavage fluid, with regard to the total number of cells in allergic Balb/c animals as compared to control mice , and in C57B6 allergic mice as compared to control mice . Allergic C57B6 mice had higher proportion of neutrophilic granulocytes in the BAL fluid than Balb/c mice .
Allergies And The Brain
Allergies that cause swelling in the lining of brain are typically caused by entire food groups, according to Prescription for Nutritional Healing, by certified nutritional expert Phyllis A. Balch 4. The most common offenders include:
- certain food additives
People with cerebral allergic edema are also susceptible to co-occurring disorders, such as headaches, aggression, violence or schizophrenia. According to Dr. Russell Roby, of the Roby Institute Allergy Treatment Center in Austin, Texas, almost all allergy symptoms are, to an extent, related to swelling and most of the headaches he sees in his allergy practice are caused by swelling, which can lead to increased pressure in the brain 6.cause
- According to Dr
of the Roby Institute Allergy Treatment Center in Austin Texas almost all allergy symptoms are to an extent most of the headaches he sees in his allergy practice are caused by swelling * which can lead to increased pressure in the brain 6.
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